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What is Arthrexin (Indocin)?

INDOMETHACIN is a non-steroidal anti-inflammatory drug (NSAID). It is used to reduce swelling and to treat pain. It may be used for painful joint and muscular problems such as arthritis, tendinitis, bursitis, and gout.

What should I tell my health care provider before I take Arthrexin (Indocin)?

They need to know if you have any of these conditions:

  • asthma, especially aspirin sensitive asthma
  • coronary artery bypass graft (CABG) surgery within the past 2 weeks
  • depression
  • drink more than 3 alcohol containing drinks a day
  • heart disease or circulation problems like heart failure or leg edema (fluid retention)
  • high blood pressure
  • kidney disease
  • liver disease
  • Parkinson's disease
  • seizures
  • stomach bleeding or ulcers
  • an unusual or allergic reaction to indomethacin, aspirin, other NSAIDs, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use Arthrexin (Indocin)?

Take Arthrexin (Indocin) by mouth with food and with a full glass of water. Take your medicine at regular intervals. Do not take your medicine more often than directed. Long-term, continuous use may increase the risk of heart attack or stroke.

Talk to your pediatrician regarding the use of Arthrexin (Indocin) in children. Special care may be needed. While this drug may be prescribed for children as young as 15 years for selected conditions, precautions do apply.

Elderly patients over 65 years old may have a stronger reaction and need a smaller dose.

Overdosage: If you think you have taken too much of Arthrexin (Indocin) contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share Arthrexin (Indocin) with others.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with Arthrexin (Indocin)?

Do not take Arthrexin (Indocin) with any of the following medications:

  • cidofovir
  • diflunisal
  • ketorolac
  • methotrexate
  • pemetrexed
  • triamterene

This medicine may also interact with the following medications:

  • alcohol
  • antacids
  • aspirin and aspirin-like medicines
  • cyclosporine
  • digoxin
  • diuretics
  • lithium
  • medicines for diabetes
  • medicines for high blood pressure
  • medicines that affect platelets
  • medicines that treat or prevent blood clots like warfarin
  • NSAIDs, medicines for pain and inflammation, like ibuprofen or naproxen
  • probenecid
  • steroid medicines like prednisone or cortisone

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using Arthrexin (Indocin)?

Tell your doctor or health care professional if your pain does not get better. Talk to your doctor before taking another medicine for pain. Do not treat yourself.

This medicine does not prevent heart attack or stroke. In fact, Arthrexin (Indocin) may increase the chance of a heart attack or stroke. The chance may increase with longer use of Arthrexin (Indocin) and in people who have heart disease. If you take aspirin to prevent heart attack or stroke, talk with your doctor or health care professional.

Do not take medicines such as ibuprofen and naproxen with Arthrexin (Indocin). Side effects such as stomach upset, nausea, or ulcers may be more likely to occur. Many medicines available without a prescription should not be taken with Arthrexin (Indocin).

This medicine can cause ulcers and bleeding in the stomach and intestines at any time during treatment. Do not smoke cigarettes or drink alcohol. These increase irritation to your stomach and can make it more susceptible to damage from Arthrexin (Indocin). Ulcers and bleeding can happen without warning symptoms and can cause death.

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how Arthrexin (Indocin) affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells.

This medicine can cause you to bleed more easily. Try to avoid damage to your teeth and gums when you brush or floss your teeth.

What side effects may I notice from Arthrexin (Indocin)?

Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
  • black or bloody stools, blood in the urine or vomit
  • blurred vision
  • chest pain
  • difficulty breathing or wheezing
  • nausea or vomiting
  • slurred speech or weakness on one side of the body
  • unexplained weight gain or swelling
  • unusually weak or tired
  • yellowing of eyes or skin

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • diarrhea
  • dizziness
  • headache
  • heartburn

This list may not describe all possible side effects.

Where should I keep Arthrexin (Indocin)?

Keep out of the reach of children.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Keep container tightly closed. Throw away any unused medicine after the expiration date.

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