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What is Avotil (Compazine)?

PROCHLORPERAZINE helps to control severe nausea and vomiting. This medicine is also used to treat schizophrenia. It can also help patients who experience anxiety that is not due to psychological illness.

What should I tell my health care provider before I take Avotil (Compazine)?

They need to know if you have any of these conditions:

  • blood disorders or disease
  • dementia
  • liver disease or jaundice
  • Parkinson's disease
  • uncontrollable movement disorder
  • an unusual or allergic reaction to prochlorperazine, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use Avotil (Compazine)?

Take Avotil (Compazine) by mouth with a glass of water. Take your doses at regular intervals. Do not take your medicine more often than directed. Do not stop taking Avotil (Compazine) suddenly. This can cause nausea, vomiting, and dizziness. Ask your doctor or health care professional for advice.

Talk to your pediatrician regarding the use of Avotil (Compazine) in children. Special care may be needed. While this drug may be prescribed for children as young as 2 years for selected conditions, precautions do apply.

Overdosage: If you think you have taken too much of Avotil (Compazine) contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share Avotil (Compazine) with others.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with Avotil (Compazine)?

Do not take Avotil (Compazine) with any of the following medications:

  • amoxapine
  • antidepressants like citalopram, escitalopram, fluoxetine, paroxetine, and sertraline
  • deferoxamine
  • dofetilide
  • maprotiline
  • tricyclic antidepressants like amitriptyline, clomipramine, imipramine, nortiptyline and others

This medicine may also interact with the following medications:

  • lithium
  • medicines for pain
  • phenytoin
  • propranolol
  • warfarin

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using Avotil (Compazine)?

Visit your doctor or health care professional for regular checks on your progress.

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how Avotil (Compazine) affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may interfere with the effect of Avotil (Compazine). Avoid alcoholic drinks.

This medicine can reduce the response of your body to heat or cold. Try not to get overheated. Avoid temperature extremes, such as saunas, hot tubs, or very hot or cold baths or showers. Dress warmly in cold weather.

This medicine can make you more sensitive to the sun. Keep out of the sun. If you cannot avoid being in the sun, wear protective clothing and use sunscreen. Do not use sun lamps or tanning beds/booths.

Your mouth may get dry. Chewing sugarless gum or sucking hard candy, and drinking plenty of water may help. Contact your doctor if the problem does not go away or is severe.

What side effects may I notice from Avotil (Compazine)?

Side effects that you should report to your doctor or health care professional as soon as possible:

  • blurred vision
  • breast enlargement in men or women
  • breast milk in women who are not breast-feeding
  • chest pain, fast or irregular heartbeat
  • confusion, restlessness
  • dark yellow or brown urine
  • difficulty breathing or swallowing
  • dizziness or fainting spells
  • drooling, shaking, movement difficulty (shuffling walk) or rigidity
  • fever, chills, sore throat
  • involuntary or uncontrollable movements of the eyes, mouth, head, arms, and legs
  • seizures
  • stomach area pain
  • unusually weak or tired
  • unusual bleeding or bruising
  • yellowing of skin or eyes

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • difficulty passing urine
  • difficulty sleeping
  • headache
  • sexual dysfunction
  • skin rash, or itching

This list may not describe all possible side effects.

Where should I keep Avotil (Compazine)?

Keep out of the reach of children.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Protect from light. Throw away any unused medicine after the expiration date.



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