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What is Duodopa (Sinemet)?

CARBIDOPA; LEVODOPA is used to treat the symptoms of Parkinson's disease.

What should my health care professional know before I take Duodopa (Sinemet)?

They need to know if you have any of these conditions:

  • asthma or lung disease
  • depression or other mental illness
  • diabetes
  • glaucoma
  • heart disease, including history of a heart attack
  • irregular heart beat
  • kidney disease
  • liver disease
  • melanoma or suspicious skin lesions
  • stomach or intestine ulcers
  • an unusual or allergic reaction to levodopa, carbidopa, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I take Duodopa (Sinemet)?

Take Duodopa (Sinemet) by mouth. Remove your medicine from the bottle with dry hands. Place tablet on the tip of the tongue and allow it to melt before swallowing. Take your doses at regular intervals. Do not take your medicine more often than directed. Do not stop taking except on the advice of your doctor or health care professional.

Talk to your pediatrician regarding the use of Duodopa (Sinemet) in children. Special care may be needed.

Overdosage: If you think you have taken too much of Duodopa (Sinemet) contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share Duodopa (Sinemet) with others.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with Duodopa (Sinemet)?

Do not take Duodopa (Sinemet) with any of the following medications:

  • isoniazid, INH
  • medicines called MAO Inhibitors like Nardil, Parnate, Marplan, Eldepryl
  • procarbazine
  • reserpine

This medicine may also interact with the following medications:

  • droperidol
  • iron supplements
  • medicines for depression, anxiety, or psychotic disturbances
  • medicines for high blood pressure
  • metoclopramide
  • papaverine
  • phenytoin

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while taking Duodopa (Sinemet)?

Visit your doctor or health care professional for regular checks on your progress. It may be several weeks or months before you feel the full benefits of Duodopa (Sinemet). Continue to take your medicine on a regular schedule. Do not take any additional medicines for Parkinson's disease without first consulting with your health care provider.

You may experience a wearing of effect prior to the time for your next dose of Duodopa (Sinemet). You may also experience an on-off effect where the medicine apparently stops working for anything from a minute to several hours, then suddenly starts working again. Tell your doctor or health care professional if any of these symptoms happen to you. Your dose may need to be changed.

A high protein diet can slow or prevent absorption of Duodopa (Sinemet). Avoid high protein foods near the time of taking Duodopa (Sinemet) to help to prevent these problems. Take Duodopa (Sinemet) at least 30 minutes before eating or one hour after meals. You may want to eat higher protein foods later in the day or in small amounts. Discuss your diet with your doctor or health care professional or nutritionist.

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this drug affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol can make you more drowsy and dizzy. Avoid alcoholic drinks.

If you are diabetic, Duodopa (Sinemet) may interfere with the accuracy of some tests for sugar or ketones in the urine (does not interfere with blood tests). Check with your doctor or health care professional before changing the dose of your diabetic medicine.

This medicine may discolor the urine or sweat, making it look darker or red in color. This is of no cause for concern. However, this may stain clothing or fabrics.

What side effects may I notice from Duodopa (Sinemet)?

Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
  • anxiety, confusion, or nervousness
  • fast or irregular heartbeat
  • hallucinations
  • mood changes like aggressive behavior, depression
  • stomach pain
  • trouble passing urine
  • uncontrolled movements of the mouth, head, hands, feet, shoulders, eyelids or other unusual muscle movements

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • headache
  • loss of appetite
  • muscle twitches
  • nausea, vomiting
  • nightmares, trouble sleeping
  • unusually weak or tired

This list may not describe all possible side effects.

Where can I keep Duodopa (Sinemet)?

Keep out of the reach of children.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Protect from light and moisture. Throw away any unused medicine after the expiration date.

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